Crinone / Progesterone
Active ingredient: progesterone; 1 applicator (1.125 g available for administration gel) contains 90 mg of progesterone (8% m / m);
Medicinal form: Gel vaginal.
Pharmacotherapeutic group. Gestagens Progesterone
Code ATX G03D A04.
Crinone is a preparation of micronized progesterone in the form of a vaginal gel. Natural progesterone, which is secreted by the yellow body in the second half of the normal menstrual cycle, plays an important role in the secretory transformation of endometrium-stimulated estrogens, which makes it suitable for implantation of the fertilized egg and further support of the implanted embryo in the early stages of its development.
The Crinone preparation provides controlled and continuous release of progesterone for at least 3 days, which is achieved due to the presence of polycarbonyl polymer in the preparation.
– Treatment of infertility caused by insufficiency of the luteal phase;
– infertility treatment in the framework of IVF procedures (in vitro fertilization): in patients with normal ovulatory cycles, infertility associated with tubal diseases, endometriosis or idiopathic pathologies.
Hypersensitivity to the active substance or to any of the excipients of the drug;
uterine bleeding of unclear etiology;
known or suspected malignant tumors of the mammary glands or genital organs;
thrombophlebitis, thromboembolic disorders, acute cerebrovascular disorders – existing or in anamnesis;
Miscarriage that has not happened.
Method of administration and dose.
Treatment of infertility caused by insufficiency of the luteal phase
After ovulation, or alternatively on the 18th-21st day of the cycle, the contents of 1 applicator (1.125 g of 8% gel) are administered daily.
When used in the framework of IVF procedures
After laboratory confirmation of pregnancy enter the contents of 1 applicator (1.125 g 8% gel) daily for 30 days.
The drug is for single use vaginal administration. The drug remaining in the applicator after the introduction must be destroyed.